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Employees of the Faculty of Fundamental Medicine of Moscow State University named after MV Lomonosov investigated the effect of genotoxic stress on the stability of the genome, as well as various methods of eliminating defective cells. This condition occurs due to a variety of DNA damage and can lead to cell death. This work was supported by the Russian Science Foundation, and the article was published in the prestigious scientific journal Oncogene. Research will help improve cancer treatments.
Ensuring the stability of the genome is necessary for the normal functioning of the cell. Errors in the replication (doubling) of DNA, as well as a variety of external factors: ultraviolet radiation, chemicals, etc., can violate this stability. The very structure of the hereditary material changes in this case – this is called genotoxic stress. It is fraught with the development of cancer and other dangerous diseases. Continue reading