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Fibrinogen, what is it and why can it be increased?

Fibrinogen is a protein that is an effective indicator of the rate of blood clot formation. A fibrinogen blood test is used to detect abnormalities that can lead to thrombosis.

Most often, this type of study is prescribed to women both at the stage of pregnancy planning, and in each trimester.

Fibrinogen – what is it?

One of the protective functions of the body is the process of blood coagulation. After injury, blood clots begin to form in the blood vessels, blocking the blood flow. This reduces the risk of large blood loss.

In a normal state, fibrinogen is a colorless protein in blood cells. Due to wounds under the influence of enzymes, it is converted to fibrin. As a result, thin binder filaments appear that contribute to the fermentation and accumulation of blood clots. Thus, the level of fibrinogen is directly related to the erythrocyte sedimentation rate (ESR).

During pregnancy, the woman’s body experiences a strong hormonal surge and the restructuring of many processes. Including thrombosis. As a result of childbirth, the mother loses a large amount of blood. When the placenta is separated, a wound remains on the surface of the uterus, which should quickly heal.

That is why the level of fibrinogen normal in pregnant women is usually higher than in other women and men. However, a significant increase is also dangerous, as it can cause thrombosis. Excessive blood coagulation in the later stages can lead to gestosis.

Fibrinogen blood count and norms
In some cases, the analysis of fibrinogen is a necessary or desirable procedure:

before the operation;
to detect diseases of the circulatory system and heart;
when planning a pregnancy;
when registering a pregnant woman.
Venous blood is used as a test for determining protein levels. Blood is given in the morning, 12 hours after the last meal. The day before, you should not overexert. And it is advisable to arrive at the laboratory in advance to give yourself 15-30 minutes to rest. If you donate blood immediately after walking or running, the result may be unreliable.

You should also refrain from alcohol for a day, and from smoking for an hour before the procedure.

The amount of fibrinogen in the blood is measured in grams per liter. The fibrinogen norm in a healthy person is 2-4 g / l. The indicator may depend on age, lifestyle, pregnancy, medication.

In infants, 1.25-3 g / l is considered the norm, and in the last months of pregnancy, the level can reach 6 g / l.

As reducing factors are:

hepatitis, cirrhosis;
myeloid leukemia;
insufficient levels of vitamins C and B12;
consumption of anabolic hormones.
Consider situations in which fibrinogen is elevated:

previous injuries and burns;
after operation;
use of oral contraception;
after a stroke (within 24 hours);
with pneumonia;
after blood transfusion.
The analysis result can reach critically high indices in case of serious inflammatory processes, accompanied by cell death.

An increase in fibrinogen from the norm and a violation of blood coagulation leads to cardiovascular diseases. In this case, it is recommended to undergo therapy that lowers blood cholesterol.

Deviation of the level of fibrinogen norm is an indicator of many diseases or complications. After the analysis, the doctor makes a conclusion about the need for further examination and treatment.

Fibrinogen during pregnancy: indicators of norm and control

Verification of fibrinogen volume is an important aspect of a healthy pregnancy. The delivery of the analysis is especially important in cases where the expectant mother is at risk:

previous miscarriages;
serious complications during previous pregnancies, such as gestosis;
age over 40 years.
Throughout the entire period of pregnancy, fibrinogen normal values ​​change.

Duration in weeks Fibrinogen norm
Up to 13 2.12-4.33
13-21 2.9-5.3
21-29 3-5.7
29-35 3.2-5.7
35-42 3.5-6.5
Determination of blood coagulation helps to avoid a number of problems during gestation and after childbirth. The fact that fibrinogen is elevated during pregnancy is normal. The main thing is to ensure that the level does not become critical.

The restructuring of the female body during this period requires careful monitoring. Most of all, unhealthy women can suffer from an imbalance in blood coagulation. Gentle exercises, yoga, frequent walks in the fresh air significantly reduce the likelihood of clogging of blood vessels.

If fibrinogen is increased during pregnancy too much, then this can lead to serious abnormalities:

Late gestosis;
Preeclampsia of the fetus;
Developmental delay;
Thrombus of the pulmonary artery in the mother.
Subject to doctor’s recommendations and timely treatment after childbirth, the level of fibrinogen drops. If the delivery took place by means of a caesarean section, then the increased rate may remain for some time.

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